Transcript Analysis for Internal Biodosimetry Using Peripheral Blood from Neuroblastoma Patients Treated with 131I-mIBG, a Targeted Radionuclide
نویسندگان
چکیده
منابع مشابه
Whole-body dosimetry for individualized treatment planning of 131I-MIBG radionuclide therapy for neuroblastoma.
UNLABELLED The aims of this study were to examine the relationship between whole-body absorbed dose and hematologic toxicity and to assess the most accurate method of delivering a prescribed whole-body absorbed dose in (131)I-metaiodobenzylguanidine ((131)I-MIBG) therapy for neuroblastoma. METHODS A total of 20 children (1-12 y), 5 adolescents (13-17 y), and 1 adult (20 y) with stage 3 or 4 n...
متن کاملAcute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG).
BACKGROUND Iodine-131-metaiodobenzylguanidine ((131)I-MIBG) provides targeted radiotherapy for children with neuroblastoma. The aim of our study was to evaluate systematically the acute effects of (131)I-MIBG on blood pressure in patients with neuroblastoma and to identify possible predictors of hypertension. PROCEDURE We conducted a retrospective chart review of neuroblastoma patients who we...
متن کاملAcute Changes in Blood Pressure in Patients With Neuroblastoma Treated With 131IMetaiodobenzylguanidine (MIBG)
Neuroblastoma is an embryonal tumor derived from the peripheral sympathetic nervous system. Metastatic disease is present at diagnosis in half of the cases. Despite improvement in outcome with intensification of therapy and treatment of minimal residual disease, 15%of patients with high-risk neuroblastoma have disease that is refractory to induction chemotherapy, and more than 50% of patients w...
متن کامل131I-MIBG in the diagnosis of primary and metastatic neuroblastoma.
OBJECTIVE Neuroblastoma is the third most common malignancy of childhood. 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging. The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease. METHODS Twenty six patients provisionally diagnosed...
متن کاملTargeted therapy with low doses of 131I-MIBG is effective for disease palliation in highly refractory neuroblastoma.
BACKGROUND Palliative treatment ore remains a significant clinical problem. OBJECTIVES To retrospectively determine the clinical response to 131I-MIBG therapy at low doses in patients with refractory neuroblastoma. METHODS We performed a retrospective chart review of 10 patients with neuroblastoma treated with 1311-MIBG at Rambam Health Care Campus from 1994 to 2012. Clinical data, number o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiation Research
سال: 2016
ISSN: 0033-7587
DOI: 10.1667/rr14263.1